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Chlamydia pneumoniae

Chlamydiae are small obligate cell parasites.

The reproductive cycle of the chlamydiae comprises two developmental stages: The elementary bodies are optimally adapted to survival outside of host cells. The initial bodies, also known as reticulate bodies, are the form which the chlamydiae reproduce inside the host cells by means of transverse fission.

Three human pathogen species of chlamydiae are known: C. psitacci, C.trachomatis and C. pneumoniae (see tab.).

Species

Clinical manifestations

Mechanism of infection

C.trachomatis

Lymphogranuloma venereum (LGV) Trachoma, inclusion conjunctivitis, urethritis(nonspecific)

Direct or sexual transmission: Primary infection of ocular or urogenital mucosa.

C.pneumoniae

Infections of the respiratory tract, often subacute. Role in atherosclerosis of coronary arteries still unclear.

Only in humans, aerogenic transmission.

C.psittaci

Ornithosis (Psittacosis)

Reservoir: infected birds. Infection by inhalation of pathogen-containing dust.

Chlamydia pneumoniae: This species causes infections of the respiratory organs in humans that usually run a mild course: influenza-like infections, sinusitis, pharyngitis, bronchitis, pneumonia (atypical). Clinically silent infections are frequent. C. pneumoniae is pathogenic in humans only. The pathogen is transmitted by aerosol droplets. These infections are probably among the most frequent human Chlamydia infections.

Infections may be diagnosed by:
Microscopy: Determination eg. of initial bodies in conjunctival cells
Serology: Determination of specific antibodies based on the ELISA-technique

In the majority of cases the asymptomatic infection by Chlamydiae is a problem: The primary infection can?t be diagnosed and therefore damages (poss. chronic disease) are caused.

NovaLisaTM Chlamydia pneumoniae IgA/IgG/IgM:

Both the NovaLisa? Chlamydia trachomatis IgA/IgG/IgM ELISA and the NovaLisa? Chlamydia pneumoniae IgA/IgG/IgM ELISA is intended for the qualitative determination of IgA-/IgG-/IgM- class antibodies against Chlamydia trachomatis resp. Chlamydia pneumoniae in serum or plasma (citrate).

Specific performance characteristics:

Chlamydia pneumoniae:

 

Intraassay

Interassay

Sensitivity%

 Specificity%

 

n

Mean

CV%

 n

Mean

CV%

 

 

IgA

20

1,2

4,9

12

12

22,3

16,3

9,7

14,0

88,9

>95

IgG

20

24

0,41

1,37

7,2

4,3

12

12

9

32

10,6

5,2

>95

91.3

IgM

24

1,29

3,1

12

78,5

12,1

83.3

>95

Antigens:
Highly purified C. pneumoniae TWAR 183 antigens

Order information:

ELISA

Number of determinations

 Product number

Chlamydia pneumoniae IgA

96

CHLA0510

Chlamydia pneumoniae IgG

96

CHLG0510

Chlamydia pneumoniae IgM

96

CHLM0510