Disclaimer
Product Inserts on this website are made available for ilustration purposes only. When using one of our test kits, one must use the insert provided with the kit itself.
Coxiella burnetii (Q-Fever)
The pathogen Coxiella burnetii is a gramnegative bacterium and belongs to the family Rickettsiaceae. It is the causative agent of Q-Fever, an acute rickettsial disease.
It can be considered the most infectious disease in the world, as a human being can be infected by a single bacterium. It can be found worldwide, including tropical countries, with the exception of New Zealand. In Europe it appears as hepatitis rather than pneumonia as in the United States.
The most common manifestation is flu-like symptoms. The fever lasts approximately 7 to 14 days. The disease can progress to an atypical pneumonia, which can result in a life threatening acute respiratory distress syndrome (ARDS). Occasionally, Q fever causes hepatitis, which may be asymptomatic or becomes symptomatic with malaise, fever, liver enlargement and pain in the right upper quadrant of the abdomen.
The chronic form of Q fever is very similar to inflammation of the inner lining of the heart, which can occur months or decades following the infection. It is fatal if left untreated, however with the correct treatment the mortality rate falls under 10%.
Species | Disease | Symptoms | Mechanism of Infection |
Coxiella burnetii | Acute Q Fever: Self-limited illness, Pneumonia, Hepatitis Chonic Q Fever | Flu like symptoms with abrupt onset of fever, profuse perspiration, severe headache, muscle pain, loss of appetite, chills Q-fever endocarditis | It can be found in both humans and animals Results from inhalation of contaminated aerosols and from contact with urine, feces or milk from infected animals Incubation period: 9 to 40 hours |
Acute & Chronic Q-fever Infections:
- Acute Infection: IgM and IgG antibodies to phase 2 antigen present
- Tests available: COX2G0600 and COX2M0600
- Chronic Infection: IgG and IgA antibodies to phase 1 antigen persent
- Tests available: COX1G0600
Infections may be diagnosed by:
- PCR: Molecular detection of bacterial DNA is increasingly used
- Serology: Determination of specific antibodies based on the ELISA-technique
NovaLisa? Coxiella burnetii IgG/IgM ELISA:
The NovaLisa? Coxiella burnetii IgG/IgM ELISA is intended for the qualitative determination of IgG- and IgM- class antibodies against Coxiella burnetii in serum or plasma.
Antigens:
IgG and IgM Coxiella burnetii IgG antigens
Specific performance characteristics:
Intraassay | Interassay | Sensitiviti % | Specificity % | ||||||
n | Mean (OD) | CV% | n | Mean (NTU) | CV% | ||||
Phase 1 IgG | Low+ | 15 | 0,57 | 5,7 | 5 (2) | 9,62 | 2,4 | 88 | >90 |
High+ | 15 | 1,5 | 4,7 | 6 (2) | 27,4 | 3,5 | |||
Phase 2 IgG | Low+ | 15 | 0,42 | 3,4 | 5 (2) | 10,1 | 10,8 | >90 | >90 |
High+ | 16 | 0,78 | 2,6 | 6 (2) | 19,5 | 1,7 | |||
Phase 2 IgM | Low+ | 15 | 0,38 | 2,9 | 6 (2) | 16,8 | 7,7 | >90 | >90 |
High+ | 15 | 0,72 | 2 | 6 (2) | 19,2 | 2,4 | |||
Order information:
ELISA | Number of Determinations | Product Number |
Coxiella burnetii Phase 1 IgG | 96 | COX1G0600 |
Coxiella burnetii Phase 2 IgG | 96 | COX2G0600 |
Coxiella burnetii Phase 2 IgM | 96 | COX2M0600 |
Your Partner
Customer Service
Download
Flyer
