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Lyme Borrelia

Borrelia burgdorferi is the active causative agent for (Lyme-) Borrelia-disease. Borreliae are thin, flexible, helically wound, highly motile spirochetes (see figure).

The pathogens are transmitted by the bite of various tick species, in Europe mostly by Ixodes ricinus(sheep tick). The incubation period varies from 3 to 30 days. Left untreated, the disease goes through three stages (see table) though individual courses often deviate from the classic pattern.

Lyme disease occurs throughout the northern hemisphere. There are some endemic foci where the infection is more frequent. In endemic areas of Germany, approximately 3-7% of the larvae and 10-34% of nymphs and adult ticks are infected with Borrelia burgdorferi sensu lato. The annual incidence of acute Lyme disease (stage I) in central Europe is 20-50 cases per 100.000 inhabitants. Wild animals from rodents on up to deer are the natural reservoir of the Lyme disease Borrelia, although these species seldom come down with the disease. The ticks obtain their blood meal from these animals. 

Species

Disease

Symptoms

Mechanism of Infection

Borrelia

Lyme disease (Borreliose)

The disease goes through 3 stages:
Stage I:
After 4-8 weeks an erythema chronicum migrans (ECM) develops on the skin (sting).
Stage II:
After 3 more weeks the generalisation of the pathogens starts. Influenzalike symptoms appear. With 80 % of the patients a lymphocytic meningoradiculitis Bannwarth with facialis paresis and aseptic meningitis as well as brief attacks of arthritis and carditis develop.
Stage III:
Neurological diseases (Chronic encephalomyelitis), Acrodermatitis chronica atrophicans, Lyme-Arthritis

Transmission by the bite of various tick species

In Europe by Ixodes ricinus

In USA by Ixodes damini

Infections may be diagnosed by:

  • Microscopy: Direct determination of the pathogen is possible, but laden with uncertainties
  • Serology:    Determination of specific antibodies based on the ELISA-technique

Because of several uncharacteristic symptoms (neurological, dermatological, cardial and rheumatic manifestations may occur) the diagnosis of Lyme-disease is mostly difficult and happens pretty late. But only the earliest diagnosis leads to an efficient therapy with antibiotics. In the chronic stage the pathogens are almost untouchable. NovaLisa? Lyme Borrelia IgG ELISA:

The NovaLisa? Lyme Borrelia IgG ELISA is intended for the qualitative determination of IgG class antibodies against Borrelia burgdorferi in human serum or plasma (citrate).

Antigens:
IgG:    VlsE (recombinant) and Lysatantigens of B. burgdorferi, B. afzelii, B. garinii

Specific performance characteristics:

Intraassay

Interassay

Sensitivity

Specificity

n

CV%

n

CV%

IgG

96

2.2

3

3.4

>95%

96.7%

Order information:

ELISA

Number of Determinations

Product Number

Lyme Borrelia IgG

96

BORG0320


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Lyme Borrelia IgG